The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock.

@article{Hennessy1994TheDO,
  title={The disposition of antiparasitic drugs in relation to the development of resistance by parasites of livestock.},
  author={D. R. Hennessy},
  journal={Acta tropica},
  year={1994},
  volume={56 2-3},
  pages={
          125-41
        }
}
  • D. Hennessy
  • Published 1 March 1994
  • Biology, Medicine
  • Acta tropica
Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration
TLDR
As the duration of exposure of parasites to the toxic concentration of the anthelmintically active metabolite was prolonged, it could be assumed that intraruminal delivery of the drug would improve the efficacy of albendazole in parasitized goats.
Anthelmintics Resistance; How to Overcome it?
  • H. Shalaby
  • Medicine, Biology
    Iranian journal of parasitology
  • 2013
TLDR
Experienced control schemes should not rely on sole use of anthelmintics, but employ other, more complex and sustainable recipes, including parasite resistant breeds, nutrition, pasture management, nematode-trapping fungi, antiparasitic vaccines and botanical dewormers.
Fasciolicides: efficacy, actions, resistance and its management.
TLDR
A number of fasciolicides-salicylanilides, phenols, diamphenethide-induce a rapid paralysis of the fluke, so their action may have a neuromuscular basis, although the actions remain ill-defined.
COMBINED STRATEGIES TO CONTROL ANTINEMATICIDAL -RESISTANT GASTROINTESTINAL NEMATODES IN SMALL RUMINANTS ON ORGANIZED FARMS IN PAKISTAN
TLDR
The different strategies to control the antinematicidal resistance on organized farms in Pakistan will be elaborated.
The disposition kinetics of albendazole following the administration of single and divided doses to cattle and buffalo
  • P. Sanyal
  • Chemistry, Medicine
    Veterinary Research Communications
  • 2004
TLDR
Pharmacokinetic analysis and the disposition curve of the metabolites indicated increased uptake of the drug in both cattle and buffalo when the same total amount of theDrug was given in divided doses compared to a single dose, suggesting the divided dose schedules of administration could possibly be exploited to extend the life of the available benzimidazole anthelmintics.
Review on anthelmintic drug resistance nematodes and its methods of detection in ethiopia
TLDR
Control of gastrointestinal nematode parasites of livestock in smallholder farmer and pastoralist communities is done with limited anthelmintic drug use, or with traditional herbal remedies, and is performed mainly during the rainy seasons.
Refugia-overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance
VAN WYK J.A. 2001. Refugia-overlooked as perhaps the most potent factor concerning the development of anthelmintic resistance. Onderstepoort Journal of Veterinary Research, 68:55-67 Anthelmintic
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Evidence is presented to suggest that response to this signalling may be dependent on dietary protein supply, and the depression of appetite appears to be associated with changes in serum L3 specific IgA, perhaps implicating immune system signalling.
Incidence of a subclinical fascioliasis on antipyrine clearance and metabolite excretion in sheep.
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It is concluded that the impairment of antipyrine clearance in the course of fascioliasis could be related to the decrease in liver microsomal cytochrome P-450-dependent mono-oxygenases observed in sheep with a similar parasitic burden.
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TLDR
The transient impairment of albendazole sulphonation could be related to the decrease in liver microsomal cytochrome P450-dependent monooxygenases observed in sheep with a similar parasitic pathology.
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