The disposition of 3H-(−)noradrenaline in the Perfused cat and rabbit heart

@article{Graefe1981TheDO,
  title={The disposition of 3H-(−)noradrenaline in the Perfused cat and rabbit heart},
  author={K. -H. Graefe},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1981},
  volume={318},
  pages={71-82}
}
1. Hearts of cats and rabbits were perfused at a constant rate with 3H-(−)noradrenaline for 60–120 min. During the perfusion the rate of net removal of 3H-noradrenaline from the perfusion fluid and the rate of efflux of 3H-metabolites from the hearts were followed. From these results and from the amount of 3H-metabolites recovered from the hearts (at the end of experiments), the time course of the cumulative metabolite formation was obtained. The following metabolites were determined: 3,4… CONTINUE READING

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Kinetics of the uptake and metabolism of 3 H - ( + ) isoprenaline in the rat submaxillary gland

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The influence of the rate of perfusion on the kinetics of neuronal uptake in the rabbit isolated heart

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