The disposition and pharmacokinetics of ketoconazole in the rat.

@article{Remmel1987TheDA,
  title={The disposition and pharmacokinetics of ketoconazole in the rat.},
  author={Rory P. Remmel and Kwame N. Amoh and M M Abdel-monem},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1987},
  volume={15 6},
  pages={
          735-9
        }
}
The disposition, biliary excretion, and pharmacokinetics of ketoconazole in Sprague-Dawley rats were determined after intravenous administration. Greater than 80% of the radioactivity after a 5 mg/kg iv dose of 3H-ketoconazole was excreted in the feces. Urinary excretion was essentially complete after 48 hr; however, fecal excretion was prolonged over a 7-day period. Biliary excretion of radioactivity averaged 54.3 +/- 18.0% of the dose over a 7.5-8-hr period in pentobarbital-anesthesized rats… CONTINUE READING

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