The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

@article{Hartmann2002TheDA,
  title={The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.},
  author={Dieter Hartmann and Bart De Strooper and Lutgarde Serneels and Katleen Craessaerts and An Herreman and Wim Annaert and Lieve Umans and Torben L{\"u}bke and Anna Lena Illert and Kurt von Figura and Paul Saftig},
  journal={Human molecular genetics},
  year={2002},
  volume={11 21},
  pages={2615-24}
}
The metalloprotease ADAM 10 is an important APP alpha-secretase candidate, but in vivo proof of this is lacking. Furthermore, invertebrate models point towards a key role of the ADAM 10 orthologues Kuzbanian and sup-17 in Notch signalling. In the mouse, this function is, however, currently attributed to ADAM 17/TACE, while the role of ADAM 10 remains unknown. We have created ADAM 10-deficient mice. They die at day 9.5 of embryogenesis with multiple defects of the developing central nervous… CONTINUE READING
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