The discovery of thymus function and of thymus‐derived lymphocytes

@article{Miller2002TheDO,
  title={The discovery of thymus function and of thymus‐derived lymphocytes},
  author={J. F. A. P. Miller},
  journal={Immunological Reviews},
  year={2002},
  volume={185}
}
  • J. F. A. P. Miller
  • Published 2002
  • Biology, Medicine
  • Immunological Reviews
Summary: For centuries the thymus remained an enigmatic organ with unknown functions. The first demonstration of its crucial role in establishing the development of a normal immune system was provided in 1961, when it was shown that mice thymectomized immediately after birth had poorly developed lymphoid tissues, impaired immune responses and inordinate susceptibility to intercurrent infections. Although thymus lymphocytes were believed to be immunoincompetent, it was shown in 1967 that they… Expand
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Using a novel approach based on chemokine receptor expression, stages in the positive selection process are mapped, and a model to study αβT cell development in the absence of medullary thymic epithelial cells (mTEC) is developed, highlighting differences in the developmental requirements of conventional and regulatory CD4+ T cells. Expand
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