The discovery of the 27-nm Norwalk virus: an historic perspective.

@article{Kapikian2000TheDO,
  title={The discovery of the 27-nm Norwalk virus: an historic perspective.},
  author={Albert Z. Kapikian},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 Suppl 2},
  pages={S295-302}
}
In 1972, a 27-nm virus-like particle was discovered by use of immune electron microscopy (IEM) in an infectious stool filtrate derived from an outbreak of gastroenteritis in an elementary school in Norwalk, Ohio. IEM enabled the direct visualization of antigen-antibody interaction, as the particles were aggregated and coated by specific antibodies. This allowed the recognition and identification of a 27-nm virus-like particle that did not have a distinctive morphology, was low-titered, and was… CONTINUE READING

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