The discovery of receptor tyrosine kinases: targets for cancer therapy

@article{Gschwind2004TheDO,
  title={The discovery of receptor tyrosine kinases: targets for cancer therapy},
  author={Andreas Gschwind and Oliver Martin Fischer and Axel Ullrich},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={361-370}
}
Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine-kinase activity. They regulate diverse functions in normal cells and have a crucial role in oncogenesis. Twenty years ago, the first primary structure of a receptor tyrosine kinase, the epidermal growth factor receptor, was elucidated. The characterization of both the molecular architecture of receptor tyrosine kinases and the main functions of these proteins and their… Expand
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