The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.

@article{Duncia1990TheDO,
  title={The discovery of potent nonpeptide angiotensin II receptor antagonists: a new class of potent antihypertensives.},
  author={John V Duncia and Andrew T. Chiu and David J Carini and Gordon Gregory and Ann L Johnson and William A. Price and Gregory J Wells and Pancras C. Wong and Joseph C. Calabrese and Pieter B. M. WW. M. Timmermans},
  journal={Journal of medicinal chemistry},
  year={1990},
  volume={33 5},
  pages={1312-29}
}
A new class of potent antihypertensives has been discovered that exert their effect through blockade of the angiotensin II (AII) receptor. Most AII antagonists reported so far are peptide mimics of the endogenous vasoconstrictor octapeptide angiotensin II. The compounds of this paper are nonpeptides and therefore constitute a new class of potent AII receptor antagonists. Based on the overlap of a conformation of AII with literature lead 3, a hypothesis was developed suggesting the need for an… CONTINUE READING

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