The discovery of pneumococcal type transformation: an appreciation

@article{Hayes1966TheDO,
  title={The discovery of pneumococcal type transformation: an appreciation},
  author={William Hayes},
  journal={Journal of Hygiene},
  year={1966},
  volume={64},
  pages={177 - 184}
}
  • W. Hayes
  • Published 1 June 1966
  • Biology, Medicine
  • Journal of Hygiene
The remarkable paper by Fred. Griffith on the significance of pneumococcal types, reproduced in the preceding pages of this Journal, in which it was first published 38 years ago (Griffith, 1928), describes a series of careful and painstaking experiments which show beyond doubt that the ability to produce a polysaccharide capsule can regularly be restored to ‘rough’ (R) strains of pneumococci which have lost it, by the subcutaneous inoculation of mice with a mixture of a small number of the… 

The significance of pneumococcal type transformation in the history of molecular biology and genetics

The discovery of pneumococcal transformation by Grif-fith and its in vitro analysis by A very and colleagues were crucial early steps in the proof that DNA acts as genetic material. As such, these

Interactions of Streptococcus pneumoniae with the Proteins of the Complement Pathways

Thirty-three years later, the heat-stable, specific components of the opsonic interaction (antibodies) were distinguished from nonspecific, heat-labile serum proteins, now named complement. In the

Introduction: the first 100 years

  • B. Drasar
  • Medicine, Biology
    Epidemiology and Infection
  • 2005
The journal that is now Epidemiology & Infection was founded in 1901 as the Journal of Hygiene ‘to fulfil a definite purpose by serving as a focus to English-speaking investigators for works in

References

SHOWING 1-10 OF 30 REFERENCES

IN VITRO TRANSFORMATION OF PNEUMOCOCCAL TYPES : I. A TECHNIQUE FOR INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES IN VITRO.

Previous findings on the thermal characteristics of the property of S vaccines responsible for transformation of type have been confirmed and extended.

Production of Staphylococcus Strains Resistant to Various Concentrations of Penicillin.

  • M. Demerec
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1945
The purpose of this study was to make a quantitative survey of the origin of resistant bacteria, and to clarify the genetic aspect of the mechanism through which resistance is formed.

The Significance of Pneumococcal Types

In the course of the examination of sputum from cases of lobar pneumonia, observations have been made on the incidence of the chief types of pneumococci, and the antigens of certain Group IV strains appear to be closely related to that of Type II.

FURTHER OBSERVATIONS ON THE USE OF PNEUMOCOCCUS EXTRACTS IN EFFECTING TRANSFORMATION OF TYPE IN VITRO

  • J. Alloway
  • Biology
    The Journal of experimental medicine
  • 1933
Pneumococcus extracts highly active in inducing the in vitro transformation of the specific types of Pneumococcus have been prepared by dissolving S cells with sodium desoxycholate, precipitating the

The genetics of transformation.

Studies on the chemical nature of the substance inducing transformation of pneumococcal types; effect of desoxyribonuclease on the biological activity of the transforming substance.

It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance

Infectivity of viral nucleic acid.

Regulation of Chromosome Replication in Bacillus subtilis

The Bacillus subtilis transformation system shows that the replication of markers on the chromosomes of a strain follows a definite pattern, allowing construction of a genetic map of the entire chromosome, and the implication to the regulation of chromosome replication will be discussed.

DOUBLE MARKER TRANSFORMATIONS AS EVIDENCE OF LINKED FACTORS IN DESOXYRIBONUCLEATE TRANSFORMING AGENTS.

  • R. HotchkissJ. Marmur
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1954
The transformability of pneumococcal cultures appears to be the result of cyclical processes occurring in individual groups in the population, which can both be accentuated and apparently rendered more synchronous, by the conditioning effect of appropriate environmental change.