The discovery of pneumococcal type transformation: an appreciation
@article{Hayes1966TheDO, title={The discovery of pneumococcal type transformation: an appreciation}, author={William Hayes}, journal={Journal of Hygiene}, year={1966}, volume={64}, pages={177 - 184} }
The remarkable paper by Fred. Griffith on the significance of pneumococcal types, reproduced in the preceding pages of this Journal, in which it was first published 38 years ago (Griffith, 1928), describes a series of careful and painstaking experiments which show beyond doubt that the ability to produce a polysaccharide capsule can regularly be restored to ‘rough’ (R) strains of pneumococci which have lost it, by the subcutaneous inoculation of mice with a mixture of a small number of the…
3 Citations
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References
SHOWING 1-10 OF 30 REFERENCES
IN VITRO TRANSFORMATION OF PNEUMOCOCCAL TYPES : I. A TECHNIQUE FOR INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES IN VITRO.
- Biology
- 1931
Previous findings on the thermal characteristics of the property of S vaccines responsible for transformation of type have been confirmed and extended.
Production of Staphylococcus Strains Resistant to Various Concentrations of Penicillin.
- Medicine, BiologyProceedings of the National Academy of Sciences of the United States of America
- 1945
The purpose of this study was to make a quantitative survey of the origin of resistant bacteria, and to clarify the genetic aspect of the mechanism through which resistance is formed.
The Significance of Pneumococcal Types
- Biology, MedicineJournal of Hygiene
- 1928
In the course of the examination of sputum from cases of lobar pneumonia, observations have been made on the incidence of the chief types of pneumococci, and the antigens of certain Group IV strains appear to be closely related to that of Type II.
FURTHER OBSERVATIONS ON THE USE OF PNEUMOCOCCUS EXTRACTS IN EFFECTING TRANSFORMATION OF TYPE IN VITRO
- BiologyThe Journal of experimental medicine
- 1933
Pneumococcus extracts highly active in inducing the in vitro transformation of the specific types of Pneumococcus have been prepared by dissolving S cells with sodium desoxycholate, precipitating the…
Studies on the chemical nature of the substance inducing transformation of pneumococcal types; effect of desoxyribonuclease on the biological activity of the transforming substance.
- BiologyThe Journal of experimental medicine
- 1946
It has been shown that extremely minute amounts of purified preparations of desoxyribonuclease are capable of bringing about the complete and irreversible inactivation of the transforming substance…
Genetic transformation. I. Cellular incorporation of DNA accompanying transformation in Pneumococcus.
- BiologyBiochimica et biophysica acta
- 1957
Regulation of Chromosome Replication in Bacillus subtilis
- Biology
- 1963
The Bacillus subtilis transformation system shows that the replication of markers on the chromosomes of a strain follows a definite pattern, allowing construction of a genetic map of the entire chromosome, and the implication to the regulation of chromosome replication will be discussed.
Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus
- BiologyNature
- 1956
IN their experiments with bacteriophages, Hershey and Chase1 have shown that only the nucleic acid component plays a part in the intracellular multiplication. There are also indications that in…