The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.


Odanacatib is a potent, selective, and neutral cathepsin K inhibitor which was developed to address the metabolic liabilities of the Cat K inhibitor L-873724. Substituting P1 and modifying the P2 side chain led to a metabolically robust inhibitor with a long half-life in preclinical species. Odanacatib was more selective in whole cell assays than the… (More)
DOI: 10.1016/j.bmcl.2007.12.047