The discovery of mRNA interferases: implication in bacterial physiology and application to biotechnology.

@article{Inouye2006TheDO,
  title={The discovery of mRNA interferases: implication in bacterial physiology and application to biotechnology.},
  author={M. Inouye},
  journal={Journal of cellular physiology},
  year={2006},
  volume={209 3},
  pages={670-6}
}
  • M. Inouye
  • Published 2006 in Journal of cellular physiology
Escherichia coli contains a large number of suicide or toxin genes, whose expression leads to cell growth arrest and eventual cell death. This raises intriguing questions as to why E. coli contains so many toxin genes and what are their roles in bacterial physiology. Among these, MazF has been shown to be a sequence-specific endoribonuclease, which cleaves mRNAs at ACA sequences to completely inhibit protein synthesis. MazF is therefore called mRNA interferase. A number of other mRNA… CONTINUE READING