The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement

@article{Fralick2021TheDO,
  title={The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement},
  author={M. Fralick and B. Zinman},
  journal={Diabetologia},
  year={2021},
  volume={64},
  pages={947 - 953}
}
There has been a great deal of controversy regarding priority of discovery of insulin. Indeed, many scientists made important and, in some cases, seminal contributions to identifying the endocrine role of the pancreas and the potential for pancreatic extracts to have a glucose-lowering effect. The purpose of this article is to describe the early experiences with respect to research leading to the discovery of insulin in Toronto (ON, Canada). The experiments conducted at the University of… Expand

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References

SHOWING 1-10 OF 54 REFERENCES
A tale of two hormones
TLDR
A little more than a century ago, an arc of research began that culminated in the identification of insulin by four scientists working in Toronto, which changed the treatment of diabetes forever by providing a hormonal treatment from the pancreas that could rapidly restore bedridden, cachectic and moribund children and young adults to healthy lives. Expand
The Evolution of Insulin and How it Informs Therapy and Treatment Choices
TLDR
This work discusses how the biochemical properties of endogenous insulin were exploited to either shorten or extend the time-action profiles of injectable insulins by varying the pharmacokinetics and pharmacodynamics. Expand
Memories of the early years of insulin treatment in the UK
The Diabetes UK Golden Year Study investigated a large cohort of Nabarro Medal winners (with type 1 diabetes of over 50 years duration) for genetic and clinical markers of long-term survival. DuringExpand
The History of Insulin
TLDR
Supporting evidence for the hypothesis gradually mounted, including observations of the relationship between diabetes and damage to the pancreatic cellular system known as the islets of Langerhans, as well as the discovery and elucidation of the physiology of internal or endocrine secretions. Expand
‘The Art of Insulin Treatment:’ Diabetes, Insulin, and the 1920s
  • K. Gardner
  • Medicine
  • The Journal of medical humanities
  • 2019
TLDR
This paper examines how the discovery of insulin intersected with the rise of diabetic technology and the transfer of medical technology to the home setting to better understand the process of implementing diabetic treatment plans that required home testing, measurement, and recording of medical data. Expand
Rewriting medical history: Charles Best and the Banting and Best myth.
  • M. Bliss
  • Medicine
  • Journal of the history of medicine and allied sciences
  • 1993
TLDR
In The Discovery of Insulin, published in 1982, and its sequel, Banting: A Biography in 1984, Frederick Banting worked assiduously and with considerable success during his lifetime to spread the view that he had discovered insulin with the help of Best. Expand
The internal secretion of the pancreas.
  • C. Best
  • Medicine
  • Canadian Medical Association journal
  • 1962
TLDR
The pancreas has lent itself admirably to this procedure in the case of both internal and external secretions and is considered for consideration in a consideration of the therapeutics of pancreatic cancer. Expand
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes Mellitus
TLDR
Intensive therapy effectively delays the onset and slows the progression of diabetic retinopathy, nephropathy, and neuropathy in patients with IDDM. Expand
Prognosis of diabetics with diabetes onset before the age of thirtyone
SummaryA follow-up on three hundred and seven patients diagnosed before 1933 and before the patient was thirty-one years old was conducted as of 1.1.1973, i.e. after at least forty years of diabetes.Expand
Mortality in Type 1 Diabetes in the DCCT/EDIC Versus the General Population
TLDR
Overall mortality in the combined D CCT/EDIC cohort was similar to that of the general population but was higher in the DCCT conventional therapy group, and mortality increased significantly with increasing mean HbA1c, more so among females than males. Expand
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