Corpus ID: 32072047

The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain.

@article{dePaulis2003TheDO,
  title={The discovery of epidepride and its analogs as high-affinity radioligands for imaging extrastriatal dopamine D(2) receptors in human brain.},
  author={Tomas de Paulis},
  journal={Current pharmaceutical design},
  year={2003},
  volume={9 8},
  pages={
          673-96
        }
}
  • T. de Paulis
  • Published 2003
  • Medicine
  • Current pharmaceutical design
[(123)I]Epidepride, [(18)F]fallypride, and [(76)Br]isoremoxipride (FLB-457) and their corresponding [(11)C]labeled derivatives belong to a class of high-affinity radioligands for SPECT or PET imaging of dopamine D(2) receptors in the human brain. In contrast to previously used imaging agents, these ligands are capable of identifying extrastriatal dopamine D(2) receptors. The design of these substituted benzamides derive its origin from the atypical antipsychotic agent, remoxipride. Starting in… Expand
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