The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.
@article{Pelaez2000TheDO, title={The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.}, author={Fernando Peláez and Angeles Cabello and Gonzalo Platas and M T D{\'i}ez and Antonio Gonz{\'a}lez del Val and A Basilio and I Mart{\'a}n and Francisca Vicente and G Bills and Robert A. Giacobbe and Robert E. Schwartz and J C Onish and Maria S. Meinz and George K. Abruzzo and Amy M. Flattery and Lingsheng Kong and Myra Berman Kurtz}, journal={Systematic and applied microbiology}, year={2000}, volume={23 3}, pages={ 333-43 } }
103 Citations
FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 I. Taxonomy, Fermentation, and Biological Properties
- BiologyBioscience, biotechnology, and biochemistry
- 2005
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus…
Antifungal antibiotics from potential biocontrol microorganisms
- Biology, Chemistry
- 2006
This thesis presents isolation and structure elucidation of twenty-five antifungal antibiotics, which had all been found to suppress fungal pathogens in bioassays, and relied on NMR and MS techniques together with chemical degradation and derivatization methods, and GCMS analysis for stereochemical investigation.
FR 207944 , an Antifungal Antibiotic from Chaetomium sp . No . 217 I . Taxonomy , Fermentation , and Biological Properties
- Biology
- 2005
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus…
Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents
- BiologyScientific Reports
- 2018
A large number of poorly studied endemic plants represents a unique potential source for the discovery of novel fungal symbionts as well as host-specific endophytes not yet described, andFermentation extracts were evaluated, looking for new antifungal activities against plant and human fungal pathogens and cytotoxic activities against the human liver cancer cell line HepG2.
Microbial natural products as a source of antifungals.
- Biology, ChemistryClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- 2003
A selection of antifungal agents in early stages of development, produced by micro-organisms, is summarized in this review and some considerations related to the chemotaxonomy of the producing organisms and some issues relevant to antIFungal drug discovery are discussed.
Fungal endophytes: a potential source of antifungal compounds.
- BiologyFrontiers in bioscience
- 2012
In the present review several metabolites obtained from endophytic fungi with a potential as antifungal agents are mentioned with bioactivity including volatile organic compounds.
Endophytic Fungi as Novel Resources of natural Therapeutics
- Biology
- 2017
Endophytes are rich source of natural products displaying broad spectrum of biological activities like anticancer, antibacterial, antiviral, immunomodulatory, antidiabetic, antioxidant, anti-arthritis and anti-inflammatory.
Curvicollide D Isolated from the Fungus Amesia sp. Kills African Trypanosomes by Inhibiting Transcription
- BiologyInternational journal of molecular sciences
- 2022
It is shown that curvicollide D binds to DNA and inhibits transcription in African trypanosomes, resulting in cell death, the first report on the activity and mode of action of a member of the curvicollside family in T. brucei.
Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases
- BiologyEnvironmental microbiology
- 2018
The preliminary identification of the enfumafungin biosynthetic gene cluster (BGC) is reported based on genome sequencing, phylogenetic reconstruction, gene disruption, and cDNA sequencing studies, suggesting that efuA represents the first member of a widespread lineage of fungal SHCs.
Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway
- Biology, ChemistryIranian journal of microbiology
- 2019
This review highlights current knowledge about available antifungal agents and further issues on antIFungal drug discovery from compounds of natural origin which affect ergosterol biosynthesis and special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterols biosynthesis pathway as a novel target for rational drug design.
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Enfumafungin (1) is a hemiacetal, triterpene glycoside that was isolated from a fermentation of Hormonema sp. as a mixture of two interconverting forms. The primary structure of the major component…
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