The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.

@article{Pelaez2000TheDO,
  title={The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.},
  author={Fernando Peláez and Angeles Cabello and Gonzalo Platas and M T D{\'i}ez and Antonio Gonz{\'a}lez del Val and A Basilio and I Mart{\'a}n and Francisca Vicente and G Bills and Robert A. Giacobbe and Robert E. Schwartz and J C Onish and Maria S. Meinz and George K. Abruzzo and Amy M. Flattery and L. Kong and Myra Berman Kurtz},
  journal={Systematic and applied microbiology},
  year={2000},
  volume={23 3},
  pages={
          333-43
        }
}
FR207944, an Antifungal Antibiotic from Chaetomium sp. No. 217 I. Taxonomy, Fermentation, and Biological Properties
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus
Anti-candidal effect of endophytic fungi isolated from Calotropis gigantea
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FR 207944 , an Antifungal Antibiotic from Chaetomium sp . No . 217 I . Taxonomy , Fermentation , and Biological Properties
An antifungal antibiotic, FR207944, was isolated from the culture broth of a fungal strain Chaetomium sp. no. 217. FR207944 is a triterpene glucoside with antifungal activity against Aspergillus
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TLDR
A large number of poorly studied endemic plants represents a unique potential source for the discovery of novel fungal symbionts as well as host-specific endophytes not yet described, andFermentation extracts were evaluated, looking for new antifungal activities against plant and human fungal pathogens and cytotoxic activities against the human liver cancer cell line HepG2.
Microbial natural products as a source of antifungals.
TLDR
A selection of antifungal agents in early stages of development, produced by micro-organisms, is summarized in this review and some considerations related to the chemotaxonomy of the producing organisms and some issues relevant to antIFungal drug discovery are discussed.
Fungal endophytes: a potential source of antifungal compounds.
TLDR
In the present review several metabolites obtained from endophytic fungi with a potential as antifungal agents are mentioned with bioactivity including volatile organic compounds.
FR227244, a novel antifungal antibiotic from Myrothecium cinctum No. 002 Taxonomy, fermentation, isolation and physico-chemical properties.
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A novel antifungal antibiotic, FR227244, was isolated from the culture broth of a fungal strain No. 002 and shown to be similar to those of FR901379 which is a known 1,3-beta-glucan synthase inhibitor.
Endophytic Fungi as Novel Resources of natural Therapeutics
TLDR
Endophytes are rich source of natural products displaying broad spectrum of biological activities like anticancer, antibacterial, antiviral, immunomodulatory, antidiabetic, antioxidant, anti-arthritis and anti-inflammatory.
Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani
TLDR
It is found that the addition of XAD-16 resin resulted in four-fold higher titers in the production of cerulenin when compared to the best production conditions described in literature for the original fungal producer strain, Cephalosporium caerulens KF-140 (=Sarocladium oryzae).
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Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.
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Enfumafungin (1) is a hemiacetal, triterpene glycoside that was isolated from a fermentation of Hormonema sp. as a mixture of two interconverting forms. The primary structure of the major component
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