The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.

@article{Pelaez2000TheDO,
  title={The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.},
  author={Fernando Peláez and Angeles Cabello and Gonzalo Platas and M T D{\'i}ez and Antonio Gonz{\'a}lez del Val and A Basilio and I Mart{\'a}n and Francisca Vicente and G Bills and Robert A. Giacobbe and Robert E. Schwartz and J C Onish and Maria S. Meinz and George K. Abruzzo and Amy M. Flattery and Lingsheng Kong and Myra Berman Kurtz},
  journal={Systematic and applied microbiology},
  year={2000},
  volume={23 3},
  pages={
          333-43
        }
}

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This review highlights current knowledge about available antifungal agents and further issues on antIFungal drug discovery from compounds of natural origin which affect ergosterol biosynthesis and special attention is made to the fungal sterol C24-methyltransferase (SMT), a crucial enzyme in ergosterols biosynthesis pathway as a novel target for rational drug design.
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