The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.

@article{Bond2015TheDO,
  title={The discovery of 1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 1.},
  author={Silas Bond and Alistair G Draffan and Jennifer E Fenner and John N. Lambert and Chin Yu Lim and Bo Lin and Angela Luttick and Jeffrey P Mitchell and Craig J Morton and Roland H Nearn and Vanessa Sanford and Pauline C Stanislawski and Simon P Tucker},
  journal={Bioorganic & medicinal chemistry letters},
  year={2015},
  volume={25 4},
  pages={969-75}
}
Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. Compound 1a (9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one) was identified as an inhibitor of A and B strains of RSV targeting the fusion glycoprotein. SAR was developed by systematic exploration of the phenyl (R(1)) and benzoyl (R(2)) groups. Furthermore, introduction of a nitrogen at the 8-position of the tricyclic core… CONTINUE READING