The discovery of antidepressants: A winding path

@article{Pletscher2005TheDO,
  title={The discovery of antidepressants: A winding path},
  author={A. Pletscher},
  journal={Experientia},
  year={2005},
  volume={47},
  pages={4-8}
}
  • A. Pletscher
  • Published 2005
  • Medicine, Biology
  • Experientia
  • Modern treatment of mental depression started with the availability of monoamine oxidase (MAO) inhibitors and tricyclic antidepressants. These drugs also contributed to the early development of psychopharmacology. Attempts to improve the anti-tuberculous action of the hydrazine derivative isoniazid by developing derivatives thereof led to the synthesis of iproniazid. Its introduction as the first modern antidepressant was based on three unexpected actions of the drug: MAO-inhibition, ‘reversal… CONTINUE READING
    Rapid-acting antidepressants: Shared neuropharmacological mechanisms
    Cerebral MAO Activity Is Not Altered by a Novel Herbal Antidepressant Treatment
    Possible directions for the discovery of new antidepressant treatments.
    1

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 21 REFERENCES
    Action of isonicotinic acid hydrazide and related compounds on enzymes involved in the autonomic nervous system
      Die Behandlung depressiver Zust / inde mit einem Iminodibenzylderivat ( G 22355 )
      • 1957
      Modifica - tion of pharmacology of reserpine and serotonin by iproniazid
      • 1956