The discovery of antidepressants: A winding path

@article{Pletscher2005TheDO,
  title={The discovery of antidepressants: A winding path},
  author={A. Pletscher},
  journal={Experientia},
  year={2005},
  volume={47},
  pages={4-8}
}
Modern treatment of mental depression started with the availability of monoamine oxidase (MAO) inhibitors and tricyclic antidepressants. These drugs also contributed to the early development of psychopharmacology. Attempts to improve the anti-tuberculous action of the hydrazine derivative isoniazid by developing derivatives thereof led to the synthesis of iproniazid. Its introduction as the first modern antidepressant was based on three unexpected actions of the drug: MAO-inhibition, ‘reversal… Expand
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