The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.

@article{Levin2001TheDO,
  title={The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.},
  author={Jeremy I. Levin and James M. Chen and Mila T Du and Margaret Hogan and Stephanie Kincaid and Frances C. Nelson and Aranapakam M Venkatesan and Tammy Wehr and Arie Zask and John F Dijoseph and Loran M Killar and Stacey Skala and Amy Sung and Michele A Sharr and Catherine E Roth and Guixian Jin and Rebecca A. Cowling and Kendall M. Mohler and Roy Black and Carl J. March and Jerauld S Skotnicki},
  journal={Bioorganic & medicinal chemistry letters},
  year={2001},
  volume={11 16},
  pages={2189-92}
}
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 inhibitor 4p. 

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