The discovery of adenosine triphosphate and the establishment of its structure

  title={The discovery of adenosine triphosphate and the establishment of its structure},
  author={Koscak Maruyama},
  journal={Journal of the History of Biology},
  • K. Maruyama
  • Published 1991
  • Biology
  • Journal of the History of Biology
ATP (adenosine triphosphate) is common to all organisms from bacteria to mammals. It is the key substance, the general currency in energy conversions within living organisms: when its terminal high-energy phosphate bond is hydrolyzed, free energy becomes available for biological activities such as muscle contraction, nerve excitation, and active transport, and also for the synthesis of a number of compounds, including proteins and nucleic acids in cells. To be useful, however, ATP hydrolysis… 

The discovery of oxidative phosphorylation: a conceptual off-shoot from the study of glycolysis.

  • J. Prebble
  • Biology, Chemistry
    Studies in history and philosophy of biological and biomedical sciences
  • 2010

On the Importance of ATP Energy in Biology with Regard to Viruses

The debate amongst biologists which concerns whether viruses are alive or not still remains unresolved because of the argument that viruses cannot produce their own adenosine triphosphate molecule through metabolism and, therefore, must rely on other living microorganisms that can produce it in order to access the energy that ATP provides upon hydrolysis.

Residue propensities, discrimination and binding site prediction of adenine and guanine phosphates

How single amino acid propensities for these nucleotide play a role in the affinity and specificity of this set of nucleotides is explored and is expected to be helpful in identifying novel binding sites for adenine and guanine phosphates.

Ecto-nucleotidases, molecular properties and functional impact

Ecto-nucleotidases hydrolyze extracellular nucleotides and modulate ligand availability at nucleotide and adenosine receptors to modulate tissue distribution and functional properties.

Purinergic signaling during rat embryonic development

Results indicated that widespread and dynamic expression of P2 receptors was found in the three-germ layer-derived embryonic tissues, particularly in some transient embryonic structures during development, which suggested they may be important in embryonic organogenesis.

Mechanism of Muscular Contraction

  • J. Rall
  • Biology
    Perspectives in Physiology
  • 2014
This chapter discusses the development of the Sliding Filament Model of Muscular Contraction, as well as the role of Calcium in Contraction and Relaxation in the 1950s and 1960s.

TSC_ATP: A two-stage classifier for predicting protein-ATP binding sites from protein sequence

  • Bryan J. AndrewsJing Hu
  • Computer Science, Biology
    2015 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)
  • 2015
This paper presents a computational method that can accurately predict ATP-binding sites on proteins using sequence-derived information and achieves an AUC of 0.829 and 0.860 respectively on two benchmark datasets.

An ATP responsive fluorescent supramolecular assembly based on a polyelectrolyte and an AIE active tetraphenylethylene derivative.

The specific recognition of an important bioanalyte, ATP, has been achieved using the formed Su-TPE-PAH supramolecular aggregate assembly as a sensing platform which displays good selectivity and high sensitivity towards ATP.