The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.

Abstract

Glucokinase is a key enzyme in glucose homeostasis since it phosphorylates glucose to give glucose-6-phosphate, which is the first step in glycolysis. GK activators have been proven to lower blood-glucose, and therefore have potential as treatments for type 2 diabetes. Here the discovery of pyrazolopyrimidine GKAs is reported. An original singleton hit from… (More)
DOI: 10.1016/j.bmcl.2012.10.090

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Cite this paper

@article{Bonn2012TheDO, title={The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.}, author={Peter Bonn and David M. Brink and Jonas F{\"a}gerhag and Ulrik Jurva and Graeme R Robb and Volker Schnecke and Anette Svensson Henriksson and Michael J. Waring and Christer Westerlund}, journal={Bioorganic & medicinal chemistry letters}, year={2012}, volume={22 24}, pages={7302-5} }