The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides.


Multiple classes of commercially important auxin herbicides have been discovered since the 1940s including the aryloxyacetates (2,4-D, MCPA, dichlorprop, mecoprop, triclopyr, and fluroxypyr), the benzoates (dicamba), the quinoline-2-carboxylates (quinclorac and quinmerac), the pyrimidine-4-carboxylates (aminocyclopyrachlor), and the pyridine-2-carboxylates (picloram, clopyralid, and aminopyralid). In the last 10 years, two novel pyridine-2-carboxylate (or picolinate) herbicides were discovered at Dow AgroSciences. This paper will describe the structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex™ active (2005) and Rinskor™ active (2010). While Arylex was developed primarily for use in cereal crops and Rinskor is still in development primarily for use in rice crops, both herbicides will also be utilized in additional crops.

DOI: 10.1016/j.bmc.2015.08.011

13 Figures and Tables

Cite this paper

@article{Epp2016TheDO, title={The discovery of Arylex™ active and Rinskor™ active: Two novel auxin herbicides.}, author={Jeffrey B Epp and Anita L Alexander and Terry W Balko and Ann M Buysse and William K. Brewster and Kristy K Bryan and John F Daeuble and Stephen C Fields and Roger E Gast and Renard A Green and Nicholas M Irvine and William C Lo and Christian T Lowe and James M. Renga and John S Richburg and James M Ruiz and Norbert M Satchivi and Paul R. Schmitzer and Thomas L Siddall and Jeffery D. Webster and Monte R Weimer and Gregory T Whiteker and Carla N Yerkes}, journal={Bioorganic & medicinal chemistry}, year={2016}, volume={24 3}, pages={362-71} }