The discovery and development of vilazodone for the treatment of depression: a novel antidepressant or simply another SSRI?

@article{Dawson2013TheDA,
  title={The discovery and development of vilazodone for the treatment of depression: a novel antidepressant or simply another SSRI?},
  author={Lee A. Dawson},
  journal={Expert Opinion on Drug Discovery},
  year={2013},
  volume={8},
  pages={1529 - 1539}
}
  • L. Dawson
  • Published 21 November 2013
  • Biology, Psychology
  • Expert Opinion on Drug Discovery
Introduction: Vilazodone is the newest serotonergic antidepressant to be approved by the FDA for the treatment of major depressive disorder (MDD). Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. It was originally designed based on the premise that negative feedback circuitry mediated through somatodendritic 5-HT1 autoreceptors, limits the acute SSRI-induced enhancements in serotonergic neurotransmission. Therefore, the combination of… 
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