The discovery and development of rivaroxaban.

  title={The discovery and development of rivaroxaban.},
  author={Frank Misselwitz and Scott D. Berkowitz and Elisabeth Perzborn},
  journal={Annals of the New York Academy of Sciences},
Thromboembolic conditions present a considerable challenge to healthcare services because they are associated with substantial morbidity and mortality. The mainstays of prevention and treatment are anticoagulants and antiplatelet agents. Established anticoagulants have drawbacks that make their use difficult to manage and sustain. This has stimulated the search for new oral anticoagulants that are more convenient and yet still effective. This paper describes the development and future potential… CONTINUE READING