The discovery and development of atorvastatin, a potent novel hypolipidemic agent.

@article{Roth2002TheDA,
  title={The discovery and development of atorvastatin, a potent novel hypolipidemic agent.},
  author={Bruce D. Roth},
  journal={Progress in medicinal chemistry},
  year={2002},
  volume={40},
  pages={1-22}
}
The search for potent and efficacious inhibitors of the enzyme HMG-CoA reductase (HMGRI) was the focus of considerable research in the 1980s. Building on the discovery of the fungal metabolite-derived inhibitors, mevastatin, lovastatin, pravastatin and simvastatin, a number of totally synthetic inhibitors were discovered and developed. This manuscript… CONTINUE READING