The discovery and development of analgesics: new mechanisms, new modalities.

@article{Burgess2010TheDA,
  title={The discovery and development of analgesics: new mechanisms, new modalities.},
  author={Gillian Munro Burgess and Dic Williams},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 11},
  pages={
          3753-9
        }
}
Despite intensive research into pain mechanisms and significant investment in research and development, the majority of analgesics available to prescribers and patients are based on mechanistic classes of compounds that have been known for many years. With considerable ingenuity and innovation, researchers continue to make the best of the mechanistic approaches available, with novel formulations, routes of administration, and combination products. Here we review some of the mechanisms and… CONTINUE READING

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