The disconnection hypothesis

  title={The disconnection hypothesis},
  author={Karl J. Friston},
  journal={Schizophrenia Research},
  • Karl J. Friston
  • Published 10 March 1998
  • Psychology, Biology
  • Schizophrenia Research

Dysfunctional connectivity in schizophrenia.

  • Karl J. Friston
  • Psychology
    World psychiatry : official journal of the World Psychiatric Association
  • 2002
The disconnection hypothesis is reviewed and its implications for how one might use the powerful tools that are emerging from functional neuroimaging and genomics, to pinpoint the mechanisms that might cause schizophrenia.

Synaptic Plasticity and Dysconnection in Schizophrenia

A neural plasticity perspective on the schizophrenic condition

Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms

Convergent evidence of discoordinated brain circuits in schizophrenia is brought together at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large‐scale brain networks.

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

It is argued that this neurobiological mechanism can explain failures of self-monitoring, leading to a mechanistic explanation for first-rank symptoms as pathognomonic features of schizophrenia, and may provide a basis for future diagnostic classifications with physiologically defined patient subgroups.

Disorganization of Oscillatory Activity in Animal Models of Schizophrenia

The potential role of oscillatory circuits in schizophrenia is reviewed with a particular focus on the hippocampus, a region that encodes sequential information across time and space, as well as the frontal cortex, to describe how these oscillations are affected in several animal models of schizophrenia.

The Developmental Neurobiology of Brain Connectivity in Schizophrenia

Studies utilizing diffusion tensor imaging (DTI) have shown a decrease in the coherence of white matter tracts in schizophrenia, presumed to be additional evidence for disrupted connectivity in schizophrenia.

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

Together, these findings suggest that the affective dysregulation of BD arises from dynamic instabilities in interoceptive circuits which subsequently impact on fear circuitry and cognitive control systems.

Splitting in Schizophrenia: Controversies and Links Between Neuroscience and Psychodynamic Theory

Basic neuroscience theories of schizophrenia that complementarily reflect mind-brain information connectivity are reviewed to suggest underlying disruptions of neural integrity might represent neural correlates of the splitting in schizophrenia that provide novel descriptions of mind- brain relationships.

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

Major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia are presented and future prospects that need to be explored are discussed.



Neural plasticity in schizophrenia.

  • J. Haracz
  • Psychology, Medicine
    Schizophrenia bulletin
  • 1985
The present article demonstrates how neural plasticity concepts can be invoked to explain the following seemingly disparate features of schizophrenia: the pharmacological support for the dopamine hypothesis, the delayed onset and offset of neuroleptic antipsychotic action, genetic and environmental influences in schizophrenia, the regional alterations in brain structure and function seen in chronic schizophrenic patients, and the various types of behavioral symptoms exhibited by schizophrenia patients.

Brain synaptic plasticity in schizophrenia

There was an anomalous sprouting of axons and a trend to increase the numerical density of axospinous synapses and to decrease axodendritic synapses in the schizophrenic brains due to disontogenesis or anomalous synaptic plasticity.

Theoretical neurobiology and schizophrenia.

This chapter addresses the idea that schizophrenia is a 'disconnection syndrome' from a theoretical and computational perspective and relates observations on the dimensional complexity of neuronal dynamics in schizophrenia to the disconnection hypothesis.

[Brain synaptic plasticity in schizophrenia].

  • N. Uranova
  • Psychology, Medicine
    Vestnik Rossiiskoi akademii meditsinskikh nauk
  • 1996
There was an anomalous sprouting of axons and a trend to increase the numerical density of axospinous synapses and to decrease axodendritic synapses in the schizophrenic brains due to disontogenesis or anomalous synaptic plasticity.

Schizophrenia and the corpus callosum: Developmental, structural and functional relationships

  • A. David
  • Psychology, Medicine
    Behavioural Brain Research
  • 1994

Biology of schizophrenia and affective disease

The biology of stress: from periphery to brain, norepinephrine and serotonin transporters, and Mechanism of action of antidepressants: monoamine hypotheses and beyond.

Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia.

A disturbance in the internal representation of contextual information can provide a common explanation for schizophrenic deficits in several attention- and language-related tasks and shows that these behavioral deficits may arise from a disturbance in a model parameter corresponding to the neuromodulatory effects of dopamine.

The Neuropsychology of Memory

This paper presents a summary of presently available information about the neuropsychology of human memory, emphasizing three ideas: a) the neural substrate of memory continues to change for a long time after initial learning, which is distinct from the changes underlying forgetting and involves the medial temporal region of the brain.

Implications of normal brain development for the pathogenesis of schizophrenia.

  • D. Weinberger
  • Psychology, Medicine
    Archives of general psychiatry
  • 1987
The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.

Parallel distributed processing and the emergence of schizophrenic symptoms.

How PDP concepts can contribute to the understanding of schizophrenic symptoms is reviewed, and certain deficit symptoms are postulated outcomes of parasitic foci located at different levels of language processing.