The disconnection hypothesis

@article{Friston1998TheDH,
  title={The disconnection hypothesis},
  author={Karl J. Friston},
  journal={Schizophrenia Research},
  year={1998},
  volume={30},
  pages={115-125}
}
  • Karl J. Friston
  • Published 10 March 1998
  • Psychology, Biology
  • Schizophrenia Research

Dysfunctional connectivity in schizophrenia.

  • Karl J. Friston
  • Psychology
    World psychiatry : official journal of the World Psychiatric Association
  • 2002
TLDR
The disconnection hypothesis is reviewed and its implications for how one might use the powerful tools that are emerging from functional neuroimaging and genomics, to pinpoint the mechanisms that might cause schizophrenia.

Synaptic Plasticity and Dysconnection in Schizophrenia

A neural plasticity perspective on the schizophrenic condition

Neural and neuronal discoordination in schizophrenia: From ensembles through networks to symptoms

TLDR
Convergent evidence of discoordinated brain circuits in schizophrenia is brought together at multiple levels of resolution, ranging from principal cells and interneurons, neuronal ensembles and local circuits, to large‐scale brain networks.

Dysconnection in Schizophrenia: From Abnormal Synaptic Plasticity to Failures of Self-monitoring

TLDR
It is argued that this neurobiological mechanism can explain failures of self-monitoring, leading to a mechanistic explanation for first-rank symptoms as pathognomonic features of schizophrenia, and may provide a basis for future diagnostic classifications with physiologically defined patient subgroups.

Disorganization of Oscillatory Activity in Animal Models of Schizophrenia

TLDR
The potential role of oscillatory circuits in schizophrenia is reviewed with a particular focus on the hippocampus, a region that encodes sequential information across time and space, as well as the frontal cortex, to describe how these oscillations are affected in several animal models of schizophrenia.

The Developmental Neurobiology of Brain Connectivity in Schizophrenia

TLDR
Studies utilizing diffusion tensor imaging (DTI) have shown a decrease in the coherence of white matter tracts in schizophrenia, presumed to be additional evidence for disrupted connectivity in schizophrenia.

Connectomics of bipolar disorder: a critical review, and evidence for dynamic instabilities within interoceptive networks

TLDR
Together, these findings suggest that the affective dysregulation of BD arises from dynamic instabilities in interoceptive circuits which subsequently impact on fear circuitry and cognitive control systems.

Splitting in Schizophrenia: Controversies and Links Between Neuroscience and Psychodynamic Theory

TLDR
Basic neuroscience theories of schizophrenia that complementarily reflect mind-brain information connectivity are reviewed to suggest underlying disruptions of neural integrity might represent neural correlates of the splitting in schizophrenia that provide novel descriptions of mind- brain relationships.

Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia

TLDR
Major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia are presented and future prospects that need to be explored are discussed.
...

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