The disappearing Barr body in breast and ovarian cancers

  title={The disappearing Barr body in breast and ovarian cancers},
  author={Gayle J. Pageau and Lisa L. Hall and Shridar Ganesan and David M. Livingston and J B Lawrence},
  journal={Nature Reviews Cancer},
Interest has recently reawakened in whether loss of the heterochromatic X chromosome (Barr body) is prevalent in certain breast and ovarian cancers, and new insights into the mechanisms involved have emerged. Mitotic segregation errors commonly explain the loss of the inactive X chromosome (Xi), but compromise of Xi heterochromatin in some cancers may signal broader deficits of nuclear heterochromatin. The debated link between BRCA1 and Xi might reflect a general relationship between BRCA1 and… CONTINUE READING

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