The disaggregation activity of the mitochondrial ClpB homolog Hsp78 maintains Hsp70 function during heat stress.

@article{Janowsky2006TheDA,
  title={The disaggregation activity of the mitochondrial ClpB homolog Hsp78 maintains Hsp70 function during heat stress.},
  author={Birgit von Janowsky and Tamara Major and Karin Knapp and Wolfgang Voos},
  journal={Journal of molecular biology},
  year={2006},
  volume={357 3},
  pages={793-807}
}
Molecular chaperones are important components of mitochondrial protein biogenesis and are required to maintain the organellar function under normal and stress conditions. We addressed the functional role of the Hsp100/ClpB homolog Hsp78 during aggregation reactions and its functional cooperation with the main mitochondrial Hsp70, Ssc1, in mitochondria of the yeast Saccharomyces cerevisiae. By establishing an aggregation/disaggregation assay in intact mitochondria we demonstrated that Hsp78 is… CONTINUE READING

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