The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged.

@article{Dominguez2015TheDO,
  title={The direction of migration of T-lymphocytes under flow depends upon which adhesion receptors are engaged.},
  author={George A Dominguez and Nicholas R. Anderson and D. Hammer},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 3},
  pages={
          345-55
        }
}
  • George A Dominguez, Nicholas R. Anderson, D. Hammer
  • Published 2015
  • Biology, Medicine
  • Integrative biology : quantitative biosciences from nano to macro
  • T-lymphocyte migration is important for homing, cell trafficking, and immune surveillance. T-lymphocytes express lymphocyte function-associated antigen-1 (LFA-1; αLβ2) and very late antigen-4 (VLA-4; α4β1), which bind to their cognate ligands, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). These adhesive interactions provide T-lymphocytes with the ability to withstand hemodynamic shear forces to facilitate adhesion and migration along the blood… CONTINUE READING
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