The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17.

@article{Suetsugu2009TheDO,
  title={The direction of actin polymerization for vesicle fission suggested from membranes tubulated by the EFC/F-BAR domain protein FBP17.},
  author={Shiro Suetsugu},
  journal={FEBS letters},
  year={2009},
  volume={583 21},
  pages={3401-4}
}
Actin polymerization mediated by the Arp2/3 complex is essential for membrane tubulation, vesicle formation and fission during clathrin-dependent endocytosis. However, the mechanism by which the polymerizing actin filaments participate in vesicle formation and fission has remained unclear. Our analyses revealed that actin polymerization occurs toward FBP17-induced membrane tubules, which are considered to be generated during endocytic vesicle formation. The tubulated membrane between the future… CONTINUE READING