The direct physiological effects of mitoK(ATP) opening on heart mitochondria.

  title={The direct physiological effects of mitoK(ATP) opening on heart mitochondria.},
  author={Alexandre Dias Tavares Costa and Casey L Quinlan and Anastasia Andrukhiv and Ian C West and Martin Jabůrek and Keith D. Garlid},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={290 1},
The mitochondrial ATP-sensitive K+ channel (mitoK(ATP)) has been assigned multiple roles in cell physiology and in cardioprotection. Each of these roles must arise from basic consequences of mitoK(ATP) opening that should be observable at the level of the mitochondrion. MitoK(ATP) opening has been proposed to have three direct effects on mitochondrial physiology: an increase in steady-state matrix volume, respiratory stimulation (uncoupling), and matrix alkalinization. Here, we examine the… CONTINUE READING


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