The direct pathway from the brainstem reticular formation to the cerebral cortex in the ascending reticular activating system: A diffusion tensor imaging study

  title={The direct pathway from the brainstem reticular formation to the cerebral cortex in the ascending reticular activating system: A diffusion tensor imaging study},
  author={Sung Ho Jang and Hyeok Gyu Kwon},
  journal={Neuroscience Letters},
  • S. Jang, H. Kwon
  • Published 8 October 2015
  • Biology, Psychology, Medicine
  • Neuroscience Letters

The Neural Tract Between the Hypothalamus and Basal Forebrain in the Ascending Reticular Activating System: A Diffusion Tensor Tractography Study.

Because the hypothalamus and BF are related to the regulation of wakefulness and sleep, the reconstruction method and results would be useful in the research on sleep and wakefulness aspects of consciousness.

Back to the Basics: Resting State Functional Connectivity of the Reticular Activation System in PTSD and its Dissociative Subtype

The present findings extend the current neurobiological model of PTSD and provide emerging evidence for the need to incorporate brainstem structures, including the reticular activation system, into current conceptualizations of PTSDand its dissociative subtype.

Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents

An evolutionarily conserved population of RAS neurons within the anterior portion of nucleus gigantocellularis (aNGC) are identified, which broadly restore cerebral cortical activation and motor behavior in rodents through the coordinated activation of multiple arousal-promoting circuits.

Prefrontal Cortical Microcircuits Support the Emergence of Mind

This chapter dwells on the high-order neural processing that underlies the emergence of the mind. We discuss the operation of microcircuits, such as neurons in different laminae of cortical columns,

[New opportunities of magnetic-resonance imaging: an algorithm of CSD-HARDI tractography in reconstruction of the brainstem reticular formation fibers].

The developed technique for reconstructing the reticular formation pathways will enable comparative analysis of examination results in patients with brain pathology accompanied by brainstem injury, which may help predict the outcome.

Electromagnetic Brain Stimulation in Patients With Disorders of Consciousness

It is proposed that all chronic DoC patients should be given the possibility to benefit from NIBS, and that transcranial direct current stimulation (tDCS) should be preferred over repetitive transcrania magnetic stimulation (rTMS), based on the literature and its simple use.

Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder

The paper examines the developmental trajectories of frontal and prefrontal lobe development, framing ADHD as maturational dysregulation concluding that the cognitive, motor, and behavioral abilities of the presumptive majority of ADHD children may not primarily be disordered or dysfunctional but reflect maturial dysregulation that is inconsistent with the psychomotor and cognitive expectations for the child's chronological and mental age.

Alterations of Brain Structural Network in Parkinson’s Disease With and Without Rapid Eye Movement Sleep Behavior Disorder

PD-pRBD exhibited a reorganization of nodal properties as well as the remapping of the hub distribution in whole brain especially in limbic system, which may shed light to the pathophysiology of PD with RBD.

The Clinical Diagnostic Utility of Electrophysiological Techniques in Assessment of Patients With Disorders of Consciousness Following Acquired Brain Injury: A Systematic Review

Investigating the diagnostic utility of electrophysiological recordings during active cognitive tasks in detecting residual cognitive capacities in patients with disorders of consciousness (DoC) after severe acquired brain injury finds electrophYSiological methods may add supplemental diagnostic information of covert cognition in some patients with DoC.



The Ascending Reticular Activating System from Pontine Reticular Formation to the Thalamus in the Human Brain

The reconstructed ARAS originated from the pontine RF, ascended through the mesencephalic tegmentum just posterior to the red nucleus, and then terminated on the intralaminar nuclei of the thalamus.

Neuroanatomic Connectivity of the Human Ascending Arousal System Critical to Consciousness and Its Disorders

This ARAS connectivity analysis provides proof of principle that HARDI tractography may affect the study of human consciousness and its disorders, including in neuropathologic studies of patients dying in coma and the persistent vegetative state.

Disconnection of the ascending arousal system in traumatic coma.

It is proposed that traumatic coma may be a subcortical disconnection syndrome related to the disconnection of specific brainstem arousal nuclei from the thalamus and basal forebrain.

Functional anatomy of arousal and attention systems in the human brain.

  • T. Paus
  • Psychology, Biology
    Progress in brain research
  • 2000

Brainstem innervation of prefrontal and anterior cingulate cortex in the rhesus monkey revealed by retrograde transport of HRP

The neurons labeled retrogradely after injection of HRP in these various regions of the frontal lobe in rhesus monkey correspond both in location and morphology to the monoamine‐containing neurons of the brainstem and are thus very likely the source of dopamine, norepinephrine, and serotonin found in the frontal cortex of the same species.


A topographical analysis of thalamo-cortical relations as revealed by alterations in the electrocorticogram induced by localized thalamic stimulation is presented, based upon the assumption that the complex spontaneous pattern of the cortex represents an aggregation of various sorts of activity.

MRI Atlas of Human White Matter

MRI Atlas of Human White Matter presents an atlas to the human brain on the basis of T 1-weighted imaging and diffusion tensor imaging, which offers a full segmentation of 220 white-matter and gray-matter structures with boundaries.

Central Thalamic Contributions to Arousal Regulation and Neurological Disorders of Consciousness

  • N. Schiff
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 2008
This review focuses on the contributions of the central thalamus to normal mechanisms of arousal regulation and to neurological disorders of consciousness and a model accounting for present therapeutic strategies is proposed.

Consciousness and the brainstem