The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation

@article{Solinas2004TheDE,
  title={The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation},
  author={G. Solinas and S. Summermatter and D. Mainieri and M. Gubler and L. Pirola and M. Wymann and S. Rusconi and J. Montani and J. Seydoux and A. Dulloo},
  journal={FEBS Letters},
  year={2004},
  volume={577}
}
  • G. Solinas, S. Summermatter, +7 authors A. Dulloo
  • Published 2004
  • Biology, Medicine
  • FEBS Letters
  • We report here studies that integrate data of respiration rate from mouse skeletal muscle in response to leptin and pharmacological interference with intermediary metabolism, together with assays for phosphatidylinositol 3‐kinase (PI3K) and AMP‐activated protein kinase (AMPK). Our results suggest that the direct effect of leptin in stimulating thermogenesis in skeletal muscle is mediated by substrate cycling between de novo lipogenesis and lipid oxidation, and that this cycle requires both PI3K… CONTINUE READING
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