The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells

@article{Wang1997TheDE,
  title={The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells},
  author={Rui Wang and Ling-Yun Wu and Zunzhe Wang},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={434},
  pages={285-291}
}
 The vasorelaxation induced by carbon monoxide (CO) has been demonstrated previously. Both a guanosine cyclic monophosphate (cGMP) signalling pathway and cGMP-independent mechanisms have been proposed to be responsible for the vascular action of CO. A direct effect of CO on the activity of calcium-activated K (KCa) channels in vascular smooth muscle cells (SMCs) and the underlying mechanisms were investigated in the present study. It was found that CO hyperpolarized single SMCs isolated from… CONTINUE READING

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