The direct association of the multiple PDZ domain containing proteins (MUPP‐1) with the human c‐Kit C‐terminus is regulated by tyrosine kinase activity

@article{Mancini2000TheDA,
  title={The direct association of the multiple PDZ domain containing proteins (MUPP‐1) with the human c‐Kit C‐terminus is regulated by tyrosine kinase activity},
  author={A. Mancini and A. Koch and M. Stefan and H. Niemann and T. Tamura},
  journal={FEBS Letters},
  year={2000},
  volume={482}
}
  • A. Mancini, A. Koch, +2 authors T. Tamura
  • Published 2000
  • Chemistry, Medicine
  • FEBS Letters
  • We have identified the multiple PDZ domain containing protein (MUPP‐1 or MPDZ) as a novel binding partner of the human c‐Kit. c‐Kit binds specifically to the 10th PDZ domain of MUPP‐1 via its C‐terminal sequence. Furthermore, a kinase negative‐mutant receptor interacted more strongly with MUPP‐1 than the wild‐type c‐Kit. Strikingly, a constitutively activated c‐Kit (D816V‐Kit) did not bind to MUPP‐1, although this oncogenic form retains the PDZ binding motif ‘HDDV’ at the C‐terminal end… CONTINUE READING
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