The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

@article{Ringelhan2015TheDA,
  title={The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.},
  author={Marc Ringelhan and Tracy O'Connor and Ulrike Protzer and Mathias Heikenwalder},
  journal={The Journal of pathology},
  year={2015},
  volume={235 2},
  pages={355-67}
}
Chronic hepatitis B virus (HBV) infection remains the number one risk factor for hepatocellular carcinoma (HCC), accounting for more than 600 000 deaths/year. Despite highly effective antiviral treatment options, chronic hepatitis B (CHB), subsequent end-stage liver disease and HCC development remain a major challenge worldwide. In CHB, liver damage is mainly caused by the influx of immune cells and destruction of infected hepatocytes, causing necro-inflammation. Treatment with nucleoside… CONTINUE READING
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