The direct activation of human multidrug resistance gene (MDR1) by anticancer agents.

@article{Kohno1989TheDA,
  title={The direct activation of human multidrug resistance gene (MDR1) by anticancer agents.},
  author={Kimitoshi Kohno and Shinichi Sato and Hirokuni Takano and Ken-ichi Matsuo and Michihiko Kuwano},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={165 3},
  pages={1415-21}
}
Enhanced expression of a multidrug-resistance gene (MDR1) is observed in some cancer patient, but any regulatory mechanisms of MDR1 gene expression in this phenomenon is not yet known. In this study, the regulation of MDR1 gene was analysed by transient expression assays in the presence of anticancer agents. We found that MDR1 promoter could be activated directly on the addition of anticancer agents including vincristine, daunomycin, adriamycin and colchicine. The results suggest that the level… CONTINUE READING

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