The diploid genome sequence of an Asian individual

@article{Wang2008TheDG,
  title={The diploid genome sequence of an Asian individual},
  author={J. Wang and W. Wang and R. Li and Y. Li and Geng Tian and L. Goodman and W. Fan and J. Zhang and J. Li and Y. Guo and Binxiao Feng and H. Li and Yao Lu and X. Fang and Huiqing Liang and Z. Du and D. Li and Yiqing Zhao and Yujie Hu and Zhenzhen Yang and Hancheng Zheng and I. Hellmann and M. Inouye and J. Pool and Xin Yi and J. Zhao and J. Duan and Y. Zhou and J. Qin and Lijia Ma and G. Li and Z. Yang and Guojie Zhang and B. Yang and C. Yu and F. Liang and W. Li and S. Li and Peixiang Ni and J. Ruan and Q. Li and H. Zhu and D. Liu and Z. Lu and N. Li and Guangwu Guo and J. Ye and L. Fang and Q. Hao and Q. Chen and Y. Liang and Yeyang Su and A. San and Cuo Ping and S. Yang and Fang Chen and L. Li and K. Zhou and H. Zheng and Y. Ren and L. Yang and Y. Gao and Guohua Yang and Zhuo Li and X. Feng and K. Kristiansen and G. K. Wong and R. Nielsen and R. Durbin and L. Bolund and X. Zhang and H. Yang},
  journal={Nature},
  year={2008},
  volume={456},
  pages={60-65}
}
  • J. Wang, W. Wang, +74 authors J. Wang
  • Published 2008
  • Biology, Medicine
  • Nature
  • Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We aligned the short reads onto the NCBI human reference genome to 99.97% coverage, and guided by the reference genome, we used uniquely mapped reads to assemble a high-quality consensus sequence for 92% of the Asian individual’s genome. We identified approximately 3 million single-nucleotide polymorphisms (SNPs) inside… CONTINUE READING
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