The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues.

@article{Brosig1998TheDM,
  title={The dimerization motif of the glycophorin A transmembrane segment in membranes: importance of glycine residues.},
  author={B Brosig and Dieter Langosch},
  journal={Protein science : a publication of the Protein Society},
  year={1998},
  volume={7 4},
  pages={1052-6}
}
The glycophorin A transmembrane segment homo-dimerizes to a right-handed pair of alpha-helices. Here, we identified the amino acid motif mediating this interaction within a natural membrane environment. Critical residues were grafted onto two different hydrophobic host sequences in a stepwise manner and self-assembly of the hybrid sequences was determined with the ToxR transcription activator system. Our results show that the motif LIxxGxxxGxxxT elicits a level of self-association equivalent to… CONTINUE READING