The dimerization domain in outer segment guanylate cyclase is a Ca²⁺-sensitive control switch module.

@article{Zgel2013TheDD,
  title={The dimerization domain in outer segment guanylate cyclase is a Ca²⁺-sensitive control switch module.},
  author={Patrick Z{\"a}gel and Daniele Dell'Orco and Karl-Wilhelm Koch},
  journal={Biochemistry},
  year={2013},
  volume={52 30},
  pages={5065-74}
}
Membrane-bound guanylate cyclases harbor a region called the dimerization or linker domain, which aids the enzymes in adopting an optimal monomer-monomer arrangement for catalysis. One subgroup of these guanylate cyclases is expressed in rod and cone cells of vertebrate retina, and mutations in the dimerization domain of rod outer segment guanylate cyclase… CONTINUE READING