The dimeric form of Ca2+-ATPase is involved in Ca2+ transport in the sarcoplasmic reticulum.

@article{Ushimaru2008TheDF,
  title={The dimeric form of Ca2+-ATPase is involved in Ca2+ transport in the sarcoplasmic reticulum.},
  author={Makoto Ushimaru and Yoshihiro Fukushima},
  journal={The Biochemical journal},
  year={2008},
  volume={414 3},
  pages={
          357-61
        }
}
To identify the functional unit of Ca(2+)-ATPase in the sarcoplasmic reticulum, we assessed Ca(2+)-transport activities occurring on sarcoplasmic reticulum membranes with different combinations of active and inactive Ca(2+)-ATPase molecules. We prepared heterodimers, consisting of a native Ca(2+)-ATPase molecule and a Ca(2+)-ATPase molecule inactivated by FITC labelling, by fusing vesicles loaded with each type of Ca(2+)-ATPase. The heterodimers exhibited neither Ca(2+) transport nor ATP… 

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