The dimer initiation sequence stem-loop of human immunodeficiency virus type 1 is dispensable for viral replication in peripheral blood mononuclear cells.

@article{Hill2003TheDI,
  title={The dimer initiation sequence stem-loop of human immunodeficiency virus type 1 is dispensable for viral replication in peripheral blood mononuclear cells.},
  author={Melissa K. Hill and Miranda Shehu-Xhilaga and Shahan M Campbell and Pantelis Poumbourios and Suzanne M. Crowe and Johnson Mak},
  journal={Journal of virology},
  year={2003},
  volume={77 15},
  pages={8329-35}
}
Human immunodeficiency virus type 1 (HIV-1) contains two copies of genomic RNA that are noncovalently linked via a palindrome sequence within the dimer initiation site (DIS) stem-loop. In contrast to the current paradigm that the DIS stem or stem-loop is critical for HIV-1 infectivity, which arose from studies using T-cell lines, we demonstrate here that HIV-1 mutants with deletions in the DIS stem-loop are replication competent in peripheral blood mononuclear cells (PBMCs). The DIS mutants… CONTINUE READING
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