The difficulties of managing severe hepatitis B virus reactivation

@article{Roche2011TheDO,
  title={The difficulties of managing severe hepatitis B virus reactivation},
  author={Bruno Roche and Didier Samuel},
  journal={Liver International},
  year={2011},
  volume={31}
}
Reactivation of hepatitis B is characterized by a sudden increase in hepatitis B virus (HBV) replication in a patient with prior evidence of resolved or inactive HBV infection. Although HBV reactivation can occur spontaneously, it usually occurs after chemotherapy, immunosuppression (organ transplantation) or an alteration in immune function (therapy for autoimmune disease, human immunodeficiency virus infection). The clinical presentation cases can vary, ranging from a subclinical… 
Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations.
TLDR
This review article will focus on when to treat, when to monitor, what patients should receive HBV therapy, and what drugs should be selected for each scenario based on both current and different HBV management guidelines.
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TLDR
HBV screening is strongly recommended for co-infected HCV/HBV patients before initiation and during DAA therapy regardless of HBV status, HCV genotype and class of DAAs used, and HBV reactivation may occur regardless of HCV Genotype and type of DAA regimen.
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TLDR
The management of rheumatology patients with HBV and HCV infection is discussed with a focus on whom to screen and whom to treat to prevent consequences of these often unrecognized conditions.
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Patients with hematological malignancies and serological signs of prior resolved hepatitis B.
TLDR
The event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM is examined and possible management strategies are proposed.
HEPATITIS B VIRUS REACTIVATION IN PATIENTS UNDERGOING CHEMOIMMUNOTHERAPY FOR HAEMATOLOGICAL MALIGNANCIES
TLDR
Clinical and epidemiological patterns of HBV reactivation in the OBI group compared to the HBV reactsivation in HBsAg positive patients (non-OBI group) during chemoimmunotherapy for HM are evaluated.
Reactivation and Flare of Chronic Hepatitis B: Natural History, Diagnosis, Therapy and Prevention
TLDR
In countries with intermediate or high endemicity for HBV, compounded in use cytotoxic or immunosuppressive therapy for the treatment of a wide variety of clinical disease, reactivation or fl are may be the first presentation of HBV infection.
Hepatitis B Virus Belated Reverse Sero-conversion After Hematopoietic Stem Cell Transplantation or Rituximab Chemotherapy
TLDR
Close follow-up of patients forHBV reverse sero-conversion even in late stages after immune suppressive and anti-cancer treatments or HSCT seems beneficial, especially in regions with intermediate or high endemicity for HBV.
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