The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

@article{Manel2008TheDO,
  title={The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt},
  author={Nicolas Manel and Derya Unutmaz and Dan R. Littman},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={641-649}
}
TH-17 cells are interleukin 17 (IL-17)–secreting CD4+ T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4+ T cells from mice, IL-17 is expressed in response to a combination of IL-6 or IL-21 and transforming growth factor-β (TGF-β) and requires induction of the nuclear receptor RORγt. It has been suggested that the differentiation of human TH-17 cells is independent of TGF-β and thus differs fundamentally from that in mice. We show here that TGF-β, IL-1β and IL-6… CONTINUE READING
Highly Influential
This paper has highly influenced 42 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
553 Citations
71 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 553 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 71 references

TGF-b–induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORgt function

  • L Zhou
  • Nature, advance online publication
  • 2008

Similar Papers

Loading similar papers…