The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity.

@article{Nuriya1996TheDR,
  title={The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity.},
  author={S Nuriya and Hideo Yagita and Katsuhiko Okumura and Masahiro Azuma},
  journal={International immunology},
  year={1996},
  volume={8 6},
  pages={
          917-26
        }
}
Contact hypersensitivity (CH) has served as a useful model for investigating the allergen-specific immune responses of T cells and skin-associated antigen-presenting cells. We examined the distinct role between CD80 and CD86 on hapten-induced CH in both an induction and an effector phase. Intraperitoneal injection of mAb against CD86, but not CD80, 2 h before sensitization with epicutaneous application of dinitrofluorobenzene led to an almost complete inhibition of ear swelling, and… CONTINUE READING

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Immunological mechanisms of contact hypersensitivity in mice.

  • APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
  • 2012
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