The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes.

@article{Malyak1998TheDP,
  title={The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes.},
  author={Mark Malyak and Michael Smith and Ashley A. Abel and Kenneth R. Hance and William P. Arend},
  journal={Journal of immunology},
  year={1998},
  volume={161 4},
  pages={
          2004-10
        }
}
IL-1R antagonist (IL-1Ra) exists as three well-characterized isoforms. The 17-kDa secretory IL-1Ra (sIL-1Ra) and 18-kDa intracellular IL-1Ra (icIL-1RaI) arise by alternative transcription of the same IL-1Ra gene. The recently described 16-kDa intracellular IL-1Ra (icIL-1RaII) is formed by alternative translation initiation of sIL-1Ra mRNA. Transcription and translation of IL-1Ra isoforms were examined in LPS-stimulated human neutrophils and PBMC using RT-PCR, ELISA, and Western blot analysis… CONTINUE READING

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