The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.

@article{Einstein2008TheDI,
  title={The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.},
  author={Monica Einstein and Taro E. Akiyama and Gino A Castriota and Chuanlin F Wang and Brian M. McKeever and Ralph T. Mosley and Joseph W. Becker and David Moller and Peter T. Meinke and Harold B. Wood and Joel P. Berger},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 1},
  pages={62-74}
}
Despite their proven antidiabetic efficacy, widespread use of peroxisome proliferator-activated receptor (PPAR)gamma agonists has been limited by adverse cardiovascular effects. To overcome this shortcoming, selective PPARgamma modulators (SPPARgammaMs) have been identified that have antidiabetic efficacy comparable with full agonists with improved tolerability in preclinical species. The results of structural studies support the proposition that SPPARgammaMs interact with PPARgamma differently… CONTINUE READING

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Distinct properties and advantages of a novel peroxisome proliferator-activated receptor [gamma] selective modulator

  • JP Berger, AE Petro, +7 authors TW Doebber
  • Mol Endocrinol
  • 2003
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