The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in-vitro HIV infection.

@article{Lisovsky2016TheDI,
  title={The differential impact of natural killer (NK) cell education via KIR2DL3 and KIR3DL1 on CCL4 secretion in the context of in-vitro HIV infection.},
  author={Irene Lisovsky and Gamze Isitman and Alexandra Tremblay-McLean and Ruifeng Song and Sandrina DaFonseca and Bertrand Lebouch{\'e} and J P Routy and Julie Bruneau and Nicole F Bernard},
  journal={Clinical and experimental immunology},
  year={2016},
  volume={186 3},
  pages={336-346}
}
Carriage of certain inhibitory natural killer (NK) cell receptor (iNKR)/HLA ligand pairs is associated with protection from infection and slow time to AIDS implicating NK cells in HIV control. NK cells acquire functional potential through education, which requires the engagement of iNKRs by their human leucocyte antigen (HLA) ligands. HIV infection down-regulates cell surface HLA-A/B, but not HLA-C/E. We investigated how NK cell populations expressing combinations of the iNKRs NKG2A, KIR2DL3… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS