The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers.

@article{McCartan2001TheDE,
  title={The differential effects of chlorpromazine and haloperidol on latent inhibition in healthy volunteers.},
  author={Damian McCartan and Robert I. Bell and James F. Green and Carl Campbell and Karl Trimble and Alan Pickering and David J. King},
  journal={Journal of psychopharmacology},
  year={2001},
  volume={15 2},
  pages={96-104}
}
Latent inhibition (LI) is a measure of reduced learning about a stimulus to which there has been prior exposure without any consequence. It therefore requires a comparison between a pre-exposed (PE) and a non-pre-exposed (NPE) condition. Since, in animals, LI is disrupted by amphetamines and enhanced by antipsychotics, LI disruption has been proposed as a measure of the characteristic attentional deficit in schizophrenia: the inability to ignore irrelevant stimuli. The findings in humans are… CONTINUE READING
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