The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation

@article{Inglis2005TheDC,
  title={The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation},
  author={Julia J. Inglis and Ahuva Nissim and Delphine M Lees and Stephen P. Hunt and Yuti Chernajovsky and Bruce L Kidd},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R807 - R816}
}
Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition. In this study, we sought to explore mechanisms by which TNF contributes to inflammatory pain in an experimental model of arthritis. The effects of an anti-TNF agent, etanercept, on behavioural pain responses arising from rat monoarthritis induced by complete Freund's adjuvant were assessed and compared with expression of TNF receptors (TNFRs… CONTINUE READING

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