The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B).

@article{BenBaruch1997TheDA,
  title={The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B).},
  author={Adit Ben-Baruch and Michael W Grimm and K M Bengali and G. A. Evans and Oleg Y. Chertov and Ji ming Wang and O. M. Zack Howard and Naofumi Mukaida and Kouji Matsushima and Joost J Oppenheim},
  journal={Journal of immunology},
  year={1997},
  volume={158 12},
  pages={5927-33}
}
IL-8 and neutrophil-activating peptide-2 (NAP-2) are two closely related C-X-C chemokines that differ in their abilities to induce chemotaxis of human polymorphonuclear leukocytes (PMN). Although two IL-8R types are expressed by PMN, only CXCR2 binds NAP-2 and IL-8 with equally high affinity. By using enriched CXCR2-transfected 293 cells, we show that high doses of IL-8 induce attenuation of chemotaxis, while equivalent doses of NAP-2 do not. Phosphorylation analysis shows that IL-8 induces… CONTINUE READING

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